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Crystal structure of the reactive loop cleaved human thyroxine binding globulin

Analyse Crystal structure of the reactive loop cleaved human thyroxine binding globulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RIV
Type: protein
Length: 373 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thyroxine-binding globulin
UniProt: P05543
Ligands: SO4
Pockets: 4 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thyroxine-binding globulin	protein	339	34% helix, 37% strand	P05543
B	Thyroxine-binding globulin	protein	34	0% helix, 56% strand	P05543

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.61	0.81	20	empty
2	132	0.44	0.76	19	empty
3	52	0.30	0.76	13	empty
4	54	0.29	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 2537 Å² buried · 33 hydrogen bonds · protein-protein

Compared structures

2RIV · Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin · the same entry in another collection · chain A against A, TM-score 1.00
P05543 · AlphaFold monomer V2.0 prediction for thyroxine-binding globulin (P05543) · a predicted model of the same protein · chain A against A, TM-score 0.92

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05543
Elsewhere: RCSB PDB 2RIV · PDBe 2RIV · UniProt P05543

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