Research workbench
Cbs domain protein PAE2072 from pyrobaculum aerophilum
Analyse Cbs domain protein PAE2072 from pyrobaculum aerophilum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2RIH
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved protein with 2 cbs domains
- UniProt
- Q8ZVX8
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved protein with 2 cbs domains | protein | 131 | 40% helix, 30% strand | Q8ZVX8 |
| B | Conserved protein with 2 cbs domains | protein | 130 | 38% helix, 29% strand | Q8ZVX8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.63 | 0.81 | 33 | SO4 |
| 2 | 136 | 0.53 | 0.81 | 22 | SO4 |
| 3 | 187 | 0.51 | 0.77 | 26 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1800 Ų buried · 30 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2RIH · CBS domain protein PAE2072 from Pyrobaculum aerophilum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZVX8
- Elsewhere: RCSB PDB 2RIH · PDBe 2RIH · UniProt Q8ZVX8
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