Research workbench

Structure of the second PDZ domain of zo-1

Analyse Structure of the second PDZ domain of zo-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RCZ
Type: protein
Length: 160 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tight junction protein zo-1
UniProt: Q07157
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tight junction protein zo-1	protein	79	18% helix, 41% strand	Q07157
B	Tight junction protein zo-1	protein	81	17% helix, 37% strand	Q07157

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.27	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 2401 Å² buried · 44 hydrogen bonds · protein-protein

Compared structures

2RCZ · Structure of the second PDZ domain of ZO-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q07157 · AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07157
Elsewhere: RCSB PDB 2RCZ · PDBe 2RCZ · UniProt Q07157

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.