Research workbench
Crystal form BH2
Analyse Crystal form BH2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R6C
- Type
- protein
- Length
- 2,562 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicative helicase; Dnag primase, helicase binding domain
- EC
- 2.7.7.-
- UniProt
- Q9X4C9, Q9X4D0
- Pockets
- 20 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Replicative helicase | protein | 358 | 48% helix, 11% strand | Q9X4C9 |
| G, H, I | Dnag primase, helicase binding domain (EC 2.7.7.-) | protein | 138 | 70% helix, 0% strand | Q9X4D0 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.67 | 0.77 | 59 | empty |
| 2 | 513 | 0.67 | 0.78 | 61 | empty |
| 3 | 597 | 0.67 | 0.77 | 65 | empty |
| 4 | 514 | 0.65 | 0.77 | 52 | empty |
| 5 | 167 | 0.64 | 0.85 | 21 | empty |
Interfaces
15 interfaces between chains.
- C–F · 1434 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 1420 Ų buried · 4 hydrogen bonds · protein-protein
- B–E · 1413 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 946 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 813 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X4C9
- Every structure of UniProt Q9X4D0
- Elsewhere: RCSB PDB 2R6C · PDBe 2R6C · UniProt Q9X4C9 · UniProt Q9X4D0
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