Research workbench
Crystal structure of the long-chain fatty acid transporter fadl mutant G212E
Analyse Crystal structure of the long-chain fatty acid transporter fadl mutant G212E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R4P
- Type
- protein
- Length
- 836 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Long-chain fatty acid transport protein
- UniProt
- P10384
- Pockets
- 9 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Long-chain fatty acid transport protein | protein | 418 | 11% helix, 54% strand | P10384 |
Ligands and binding sites
- LDA · Lauryl dimethylamine-N-oxide · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.81 | 0.96 | 30 | LDA |
| 2 | 156 | 0.80 | 0.96 | 33 | LDA |
| 3 | 337 | 0.77 | 0.88 | 50 | empty |
| 4 | 372 | 0.77 | 0.87 | 53 | empty |
| 5 | 346 | 0.62 | 0.79 | 39 | empty |
Compared structures
- 2R4P · Crystal structure of the long-chain fatty acid transporter FadL mutant G212E · the same entry in another collection · chain A against A, TM-score 1.00
- P10384 · AlphaFold monomer V2.0 prediction for long-chain fatty acid transport protein (P10384) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10384
- Elsewhere: RCSB PDB 2R4P · PDBe 2R4P · UniProt P10384
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