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The high resolution structure of the RNA-binding domain of telomerase

Analyse The high resolution structure of the RNA-binding domain of telomerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2R4G
Type: protein
Length: 250 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Telomerase reverse transcriptase
EC: 2.7.7.49
UniProt: O77448
Ligands: BR
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Telomerase reverse transcriptase (EC 2.7.7.49)	protein	250	62% helix, 4% strand	O77448

Ligands and binding sites

BR · Bromide ion · ion · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.44	0.78	19	empty

Compared structures

2R4G · The high resolution structure of the RNA-binding domain of telomerase · the same entry in another collection · chain A against A, TM-score 1.00
O77448 · AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O77448) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O77448
Elsewhere: RCSB PDB 2R4G · PDBe 2R4G · UniProt O77448

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