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Orthorhombic crystal structure of human saposin C dimer in open conformation

Analyse Orthorhombic crystal structure of human saposin C dimer in open conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QYP
Type: protein
Length: 159 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proactivator polypeptide
UniProt: P07602
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proactivator polypeptide	protein	78	74% helix, 0% strand	P07602
B	Proactivator polypeptide	protein	81	84% helix, 0% strand	P07602

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.29	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1740 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2QYP · Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation · the same entry in another collection · chain A against A, TM-score 1.00
P07602 · AlphaFold monomer V2.0 prediction for prosaposin (P07602) · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07602
Elsewhere: RCSB PDB 2QYP · PDBe 2QYP · UniProt P07602

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