UniProt P07602
Prosaposin (P07602)
Prosaposin (UniProt P07602): 34 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07602
- Protein
- Prosaposin
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 4 records with a druggable one
Structures
35 records of P07602 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M12 | NMR solution structure of human Saposin C | solution nmr | A | — | — |
| 1M12 | NMR solution structure of human saposin C | solution nmr | A | — | — |
| 1N69 | Crystal structure of human saposin B | x-ray diffraction | A, B, C | — | — |
| 1N69 | Crystal structure of human saposin B | x-ray diffraction | A, B, C | — | — |
| 1SN6 | NMR solution structure of human Saposin C in SDS micelles | solution nmr | A | — | — |
| 1SN6 | NMR solution structure of human saposin C in sds micelles | solution nmr | A | — | — |
| 2DOB | Crystal Structure of Human Saposin A | x-ray diffraction | A | — | — |
| 2DOB | Crystal structure of human saposin a | x-ray diffraction | A | — | — |
| 2GTG | Crystal Structure of Human Saposin C | x-ray diffraction | A | — | — |
| 2GTG | Crystal structure of human saposin C | x-ray diffraction | A | — | — |
| 2QYP | Orthorhombic Crystal Structure of Human Saposin C Dimer in Open Conformation | x-ray diffraction | A, B | — | — |
| 2QYP | Orthorhombic crystal structure of human saposin C dimer in open conformation | x-ray diffraction | A, B | — | — |
| 2R0R | Crystal Structure of Human Saposin D variant SapD K9E | x-ray diffraction | A, B | — | — |
| 2R0R | Crystal structure of human saposin D variant sapd K9E | x-ray diffraction | A, B | — | — |
| 2R1Q | Crystal Structure of Iodinated Human Saposin D in Space Group C2221 | x-ray diffraction | A | — | — |
| 2R1Q | Crystal structure of iodinated human saposin D in space group C2221 | x-ray diffraction | A | — | — |
| 2RB3 | Crystal Structure of Human Saposin D | x-ray diffraction | A, B, C, D | — | — |
| 2RB3 | Crystal structure of human saposin D | x-ray diffraction | A, B, C, D | — | — |
| 2Z9A | Crystal Structure of Human Saposin C Dimer in Open Conformation | x-ray diffraction | A, B | — | — |
| 2Z9A | Crystal structure of human saposin C dimer in open conformation | x-ray diffraction | A, B | — | — |
| 3BQP | Crystal Structure of Human Saposin D (orthorhombic) | x-ray diffraction | A, B | — | — |
| 3BQP | Crystal structure of human saposin D (orthorhombic) | x-ray diffraction | A, B | — | — |
| 3BQQ | Crystal Structure of Human Saposin D (triclinic) | x-ray diffraction | C, A, B, D | — | — |
| 3BQQ | Crystal structure of human saposin D (triclinic) | x-ray diffraction | C, A, B, D | — | — |
| 4DDJ | Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO) | x-ray diffraction | A | — | — |
| 4DDJ | Crystal structure of saposin a in complex with lauryldimethylamine-N- oxide (ldao) | x-ray diffraction | A | — | — |
| 4UEX | Structure of human Saposin A at lysosomal pH | x-ray diffraction | A, B | — | — |
| 4UEX | Structure of human saposin a at lysosomal pH | x-ray diffraction | A, B | — | — |
| 4V2O | Structure of saposin B in complex with chloroquine | x-ray diffraction | A, B, C | — | — |
| 4V2O | Structure of saposin B in complex with chloroquine | x-ray diffraction | A, B, C | — | — |
| 6SLR | Structure of saposin B in complex with atovaquone | x-ray diffraction | A, B, C | AOQ | 2 (best 0.71) |
| 6SLR | Structure of saposin B in complex with atovaquone | x-ray diffraction | A, B, C | AOQ | — |
| 9AVS | Human alpha-galactosidase A in complex with saposin B | x-ray diffraction | C | SO4 | 3 (best 0.80) |
| 9AXG | Human saposin B in the presence of globotriaosylceramide-NBD | x-ray diffraction | A, B | — | 1 (best 0.67) |
| P07602 | AlphaFold monomer V2.0 prediction for prosaposin (P07602) | predicted | A | — | 6 (best 0.63) |
Ligands
Experiment against prediction
- 4V2O chain B against the predicted model P07602: TM-score 0.92, RMSD 1.01 Å
- 4V2O chain B against the predicted model P07602: TM-score 0.92, RMSD 1.01 Å
- 9AVS chain C against the predicted model P07602: TM-score 0.92, RMSD 1.05 Å
- 6SLR chain B against the predicted model P07602: TM-score 0.91, RMSD 1.08 Å
- 6SLR chain B against the predicted model P07602: TM-score 0.91, RMSD 1.08 Å
- 4V2O chain A against the predicted model P07602: TM-score 0.90, RMSD 1.25 Å
- 4V2O chain A against the predicted model P07602: TM-score 0.90, RMSD 1.25 Å
- 6SLR chain C against the predicted model P07602: TM-score 0.89, RMSD 1.57 Å
- 6SLR chain C against the predicted model P07602: TM-score 0.89, RMSD 1.57 Å
- 6SLR chain A against the predicted model P07602: TM-score 0.89, RMSD 1.40 Å
Elsewhere
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