Research workbench
Crystal structure of bovine HSC70 (1-394AA)IN the apo state
Analyse Crystal structure of bovine HSC70 (1-394AA)IN the apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QW9
- Type
- protein
- Length
- 764 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock cognate 71 kda protein
- UniProt
- P19120
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heat shock cognate 71 kda protein | protein | 382 | 41% helix, 28% strand | P19120 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 400 | 0.73 | 0.84 | 55 | empty |
| 2 | 358 | 0.72 | 0.84 | 48 | empty |
| 3 | 72 | 0.65 | 0.92 | 17 | GOL |
| 4 | 377 | 0.58 | 0.76 | 31 | empty |
| 5 | 334 | 0.57 | 0.76 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 492 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2QW9 · Crystal structure of bovine hsc70 (1-394aa)in the apo state · the same entry in another collection · chain A against A, TM-score 1.00
- P19120 · AlphaFold monomer V2.0 prediction for heat shock cognate 71 kda protein (P19120) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19120
- Elsewhere: RCSB PDB 2QW9 · PDBe 2QW9 · UniProt P19120
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