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Crystal structure of the essential inner kinetochore protein CEP3P

Analyse Crystal structure of the essential inner kinetochore protein CEP3P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QUQ
Type: protein
Length: 517 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centromere DNA-binding protein complex CBF3 subunit B
UniProt: P40969
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centromere DNA-binding protein complex CBF3 subunit B	protein	517	69% helix, 1% strand	P40969

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	377	0.78	0.88	50	empty
2	134	0.61	0.85	23	empty
3	119	0.45	0.77	24	empty
4	122	0.40	0.75	31	empty
5	98	0.37	0.74	20	empty

Compared structures

2QUQ · Crystal Structure of the Essential Inner Kinetochore Protein Cep3p · the same entry in another collection · chain A against A, TM-score 1.00
P40969 · AlphaFold monomer V2.0 prediction for centromere DNA-binding protein complex CBF3 subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P40969
Elsewhere: RCSB PDB 2QUQ · PDBe 2QUQ · UniProt P40969

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