Research workbench
Solution structure of human dimeric immunoglobulin a
Analyse Solution structure of human dimeric immunoglobulin a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QTJ
- Type
- protein
- Length
- 2,756 residues
- Chains
- 8
- Method
- solution scattering
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kappa light chain IGA1; Ig alpha-1 chain C region
- UniProt
- P01876
- Pockets
- 4 · best druggability 0.39
Structure
solution scattering · 2 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, M, N, O | Kappa light chain IGA1 | protein | 214 | 0% helix, 0% strand | — |
| A, B, C, D | Ig alpha-1 chain C region | protein | 475 | 0% helix, 0% strand | P01876 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.39 | 0.73 | 28 | empty |
| 2 | 101 | 0.39 | 0.74 | 29 | empty |
| 3 | 94 | 0.37 | 0.73 | 27 | empty |
| 4 | 78 | 0.33 | 0.73 | 26 | empty |
Interfaces
9 interfaces between chains.
- A–D · 224 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 202 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 201 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 192 Ų buried · 0 hydrogen bonds · protein-protein
- N–C · 106 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2QTJ · Solution structure of human dimeric immunoglobulin A · the same entry in another collection · chain D against D, TM-score 1.00
- P01876 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy constant alpha 1 (P01876) · a predicted model of the same protein · chain A against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01876
- Elsewhere: RCSB PDB 2QTJ · PDBe 2QTJ · UniProt P01876
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.