Research workbench
Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8
Analyse Crystal structure of complement protein C8 in complex with a peptide containing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QOS
- Type
- protein
- Length
- 184 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement component 8, gamma polypeptide; Complement component C8 alpha chain
- UniProt
- Q14CU0, P07357
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Complement component 8, gamma polypeptide | protein | 173 | 21% helix, 42% strand | Q14CU0 |
| A | Complement component C8 alpha chain | protein | 11 | 0% helix, 36% strand | P07357 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.54 | 0.87 | 17 | empty |
| 2 | 54 | 0.40 | 0.81 | 17 | empty |
Interfaces
1 interface between chains.
- C–A · 757 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2QOS · Crystal structure of complement protein C8 in complex with a peptide containing the C8… · the same entry in another collection · chain C against C, TM-score 1.00
- P07357 · AlphaFold monomer V2.0 prediction for complement component C8 alpha chain (P07357) · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14CU0
- Every structure of UniProt P07357
- Elsewhere: RCSB PDB 2QOS · PDBe 2QOS · UniProt Q14CU0 · UniProt P07357
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