Crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).

Ligands and binding sites

• ZB2 · 2-O-methyl-alpha-D-glucopyranose · ligand · 2 copies · chains B
• ZB1 · 3-O-methyl-alpha-D-glucopyranose · ligand · chains B
• ZB3 · 2,6-di-O-methyl-alpha-D-glucopyranose · ligand · chains B
• ZB0 · 2,3-di-O-methyl-alpha-D-glucopyranose · ligand · chains B
• GLC · alpha-D-glucopyranose · sugar · 2 copies · chains B
• TAR · D(-)-tartaric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• B–A · 642 Ų buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

• 2QKH · Crystal structure of the extracellular domain of human GIP receptor in complex with the… · the same entry in another collection · chain B against B, TM-score 1.00
• P48546 · AlphaFold monomer V2.0 prediction for gastric inhibitory polypeptide receptor (P48546) · a predicted model of the same protein · chain A against A, TM-score 0.94
• P09681 · AlphaFold monomer V2.0 prediction for gastric inhibitory polypeptide (P09681) · a predicted model of the same protein · chain B against A, TM-score 0.72

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P09681
• Every structure of UniProt P48546
• Elsewhere: RCSB PDB 2QKH · PDBe 2QKH · UniProt P09681 · UniProt P48546