Research workbench

Crystal structure of a survivin-borealin-incenp core complex

Analyse Crystal structure of a survivin-borealin-incenp core complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QFA
Type: protein
Length: 244 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Baculoviral iap repeat-containing protein 5; Borealin; Inner centromere protein
UniProt: O15392, Q53HL2, Q9NQS7
Ligands: ZN
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 3 distinct chains · 67% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Baculoviral iap repeat-containing protein 5	protein	137	53% helix, 8% strand	O15392
B	Borealin	protein	62	89% helix, 2% strand	Q53HL2
C	Inner centromere protein	protein	45	80% helix, 0% strand	Q9NQS7

Ligands and binding sites

ZN · Zinc ion · metal · chains A
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.38	0.76	20	MES

Interfaces

3 interfaces between chains.

A–B · 1487 Å² buried · 21 hydrogen bonds · protein-protein
B–C · 1017 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 953 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2QFA · Crystal structure of a Survivin-Borealin-INCENP core complex · the same entry in another collection · chain A against A, TM-score 1.00
O15392 · AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 5… · a predicted model of the same protein · chain A against A, TM-score 0.94
Q53HL2 · AlphaFold monomer V2.0 prediction for borealin (Q53HL2) · a predicted model of the same protein · chain B against A, TM-score 0.93
Q9NQS7 · AlphaFold monomer V2.0 prediction for inner centromere protein (Q9NQS7) · a predicted model of the same protein · chain C against A, TM-score 0.63

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15392
Every structure of UniProt Q53HL2
Every structure of UniProt Q9NQS7
Elsewhere: RCSB PDB 2QFA · PDBe 2QFA · UniProt O15392 · UniProt Q53HL2 · UniProt Q9NQS7

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