UniProt Q53HL2
Borealin (Q53HL2)
Borealin (UniProt Q53HL2): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q53HL2
- Protein
- Borealin
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 2 records with a druggable one
Structures
16 records of Q53HL2 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KDD | Solution structure of the conserved C-terminal dimerization domain of Borealin | solution nmr | A, B | — | — |
| 2KDD | Solution structure of the conserved C-terminal dimerization domain of borealin | solution nmr | A, B | — | — |
| 2QFA | Crystal structure of a Survivin-Borealin-INCENP core complex | x-ray diffraction | B | — | — |
| 2QFA | Crystal structure of a survivin-borealin-incenp core complex | x-ray diffraction | B | — | — |
| 2RAW | Crystal structure of the Borealin-Survivin complex | x-ray diffraction | B | — | — |
| 2RAW | Crystal structure of the borealin-survivin complex | x-ray diffraction | B | — | — |
| 2RAX | Crystal structure of Borealin (20-78) bound to Survivin (1-120) | x-ray diffraction | B, F, Y | — | 4 (best 0.57) |
| 2RAX | Crystal structure of borealin (20-78) bound to survivin (1-120) | x-ray diffraction | B, F, Y | — | — |
| 6YIE | Structure of a Borealin-INCENP-Survivin complex | x-ray diffraction | B, E | — | 5 (best 0.70) |
| 6YIE | Structure of a borealin-incenp-survivin complex | x-ray diffraction | B, E | — | — |
| 6YIF | Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 1.8 A. | x-ray diffraction | B | SO4 | — |
| 6YIF | Structure of chromosomal passenger complex (cpc) bound to phosphorylated histone 3 peptide at 1.8 a. | x-ray diffraction | B | SO4 | — |
| 6YIH | Structure of Chromosomal Passenger Complex (CPC) bound to phosphorylated Histone 3 peptide at 2.6 A. | x-ray diffraction | B | — | 2 (best 0.42) |
| 6YIH | Structure of chromosomal passenger complex (cpc) bound to phosphorylated histone 3 peptide at 2.6 a. | x-ray diffraction | B | — | — |
| 7U5V | Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product… | x-ray diffraction | C | SAH | — |
| Q53HL2 | AlphaFold monomer V2.0 prediction for borealin (Q53HL2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2QFA chain B against the predicted model Q53HL2: TM-score 0.93, RMSD 0.81 Å
- 2QFA chain B against the predicted model Q53HL2: TM-score 0.93, RMSD 0.81 Å
- 6YIF chain B against the predicted model Q53HL2: TM-score 0.90, RMSD 0.86 Å
- 6YIF chain B against the predicted model Q53HL2: TM-score 0.90, RMSD 0.86 Å
- 6YIH chain B against the predicted model Q53HL2: TM-score 0.90, RMSD 0.95 Å
- 6YIH chain B against the predicted model Q53HL2: TM-score 0.90, RMSD 0.95 Å
- 6YIE chain B against the predicted model Q53HL2: TM-score 0.89, RMSD 1.03 Å
- 6YIE chain B against the predicted model Q53HL2: TM-score 0.89, RMSD 1.03 Å
- 6YIE chain E against the predicted model Q53HL2: TM-score 0.89, RMSD 1.03 Å
- 6YIE chain E against the predicted model Q53HL2: TM-score 0.89, RMSD 1.03 Å
Elsewhere
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