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Crystal structure of bone morphogenetic protein-6 (bmp-6)

Analyse Crystal structure of bone morphogenetic protein-6 (bmp-6) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QCW
Type: protein
Length: 208 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bone morphogenetic protein 6
UniProt: P22004
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Bone morphogenetic protein 6	protein	104	15% helix, 45% strand	P22004

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.43	0.76	31	empty
2	81	0.41	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 1201 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

2QCW · Crystal Structure of Bone Morphogenetic Protein-6 (BMP-6) · the same entry in another collection · chain A against A, TM-score 1.00
P22004 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein 6 (P22004) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22004
Elsewhere: RCSB PDB 2QCW · PDBe 2QCW · UniProt P22004

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