Research workbench
Structural insight into the enzymatic mechanism of the phophothreonine lyase
Analyse Structural insight into the enzymatic mechanism of the phophothreonine lyase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Q8Y
- Type
- protein
- Length
- 222 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 27.5 kda virulence protein; Mitogen-activated protein kinase 7
- EC
- 4.2.-.-, 2.7.11.24
- UniProt
- P0A2N1, Q13164
- Pockets
- 2 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 27.5 kda virulence protein (EC 4.2.-.-) | protein | 213 | 37% helix, 16% strand | P0A2N1 |
| B | Mitogen-activated protein kinase 7 (EC 2.7.11.24) | protein | 9 | 0% helix, 0% strand | Q13164 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.35 | 0.76 | 21 | empty |
| 2 | 51 | 0.28 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 639 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 2Q8Y · Structural insight into the enzymatic mechanism of the phophothreonine lyase · the same entry in another collection · chain A against A, TM-score 1.00
- P0A2N1 · AlphaFold monomer V2.0 prediction for MAPK phosphothreonine lyase (P0A2N1) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q13164 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 7 (Q13164) · a predicted model of the same protein · chain B against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A2N1
- Every structure of UniProt Q13164
- Elsewhere: RCSB PDB 2Q8Y · PDBe 2Q8Y · UniProt P0A2N1 · UniProt Q13164
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