UniProt Q13164
Mitogen-activated protein kinase 7 (Q13164)
Mitogen-activated protein kinase 7 (UniProt Q13164), EC 2.7.11.24: 24 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q13164
- Protein
- Mitogen-activated protein kinase 7
- EC
- 2.7.11.24
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 17 · 5 records with a druggable one
Structures
25 records of Q13164 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2Q8Y | Structural insight into the enzymatic mechanism of the phophothreonine lyase | x-ray diffraction | B | — | — |
| 2Q8Y | Structural insight into the enzymatic mechanism of the phophothreonine lyase | x-ray diffraction | B | — | — |
| 4B99 | Crystal Structure of MAPK7 (ERK5) with inhibitor | x-ray diffraction | A | — | — |
| 4B99 | Crystal structure of MAPK7 (ERK5) with inhibitor | x-ray diffraction | A | — | — |
| 4IC7 | Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment | x-ray diffraction | A, D | — | — |
| 4IC7 | Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment | x-ray diffraction | A, D | — | — |
| 4IC8 | Crystal structure of the apo ERK5 kinase domain | x-ray diffraction | A, B | — | — |
| 4IC8 | Crystal structure of the apo ERK5 kinase domain | x-ray diffraction | A, B | — | — |
| 4ZSG | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | 4QX | 4 (best 0.59) |
| 4ZSG | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4ZSJ | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | 4R0 | 4 (best 0.54) |
| 4ZSJ | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4ZSL | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | — | — |
| 4ZSL | Mitogen activated protein kinase 7 in complex with inhibitor | x-ray diffraction | A | — | — |
| 5BYY | ERK5 in complex with small molecule | x-ray diffraction | A | 4WG | 4 (best 0.70) |
| 5BYY | ERK5 in complex with small molecule | x-ray diffraction | A | — | — |
| 5BYZ | ERK5 in complex with small molecule | x-ray diffraction | A | — | — |
| 5O7I | ERK5 in complex with a pyrrole inhibitor | x-ray diffraction | A | 9N8 | — |
| 5O7I | ERK5 in complex with a pyrrole inhibitor | x-ray diffraction | A | 9N8 | — |
| 6HKM | Crystal structure of Compound 1 with ERK5 | x-ray diffraction | A | G92 | 4 (best 0.67) |
| 6HKM | Crystal structure of compound 1 with ERK5 | x-ray diffraction | A | G92 | — |
| 6HKN | Crystal structure of Compound 35 with ERK5 | x-ray diffraction | A | G9E | — |
| 6HKN | Crystal structure of compound 35 with ERK5 | x-ray diffraction | A | G9E | — |
| 7PUS | ERK5 in complex with Pyrrole Carboxamide scaffold | x-ray diffraction | AAA | 86E | 1 (best 0.74) |
| Q13164 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 7 (Q13164) | predicted | A | — | — |
Ligands
- 9N8 · 4-(2-bromanyl-6-fluoranyl-phenyl)carbonyl-~{N}-pyridin-3-yl-1~{H}-pyrrole-2-carboxamide · in 2 records
- G92 · [4-(6,7-dimethoxyquinazolin-4-yl)piperidin-1-yl]-[4-(trifluoromethyloxy)phenyl]methanone · in 2 records
- G9E · [2-azanyl-4-(trifluoromethyloxy)phenyl]-[4-(7-methoxyquinazolin-4-yl)piperidin-1-yl]methanone · in 2 records
- 4QX · 3-amino-5-[(4-chlorophenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide · in 1 record
- 4R0 · 3-amino-5-[(4-chloro-3-methylphenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide · in 1 record
- 4WG · 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-B][1, 4]benzodiazepin-6-one · in 1 record
- 86E · 4-[3,6-bis(chloranyl)-2-fluoranyl-phenyl]carbonyl-~{N}-(1-methylpyrazol-4-yl)-1~{H}-pyrrole-2-carboxamide · in 1 record
Experiment against prediction
- 5BYY chain A against the predicted model Q13164: TM-score 0.98, RMSD 1.01 Å
- 5BYY chain A against the predicted model Q13164: TM-score 0.98, RMSD 1.01 Å
- 4IC7 chain D against the predicted model Q13164: TM-score 0.98, RMSD 1.09 Å
- 4IC7 chain D against the predicted model Q13164: TM-score 0.98, RMSD 1.09 Å
- 4IC7 chain A against the predicted model Q13164: TM-score 0.98, RMSD 1.16 Å
- 4IC7 chain A against the predicted model Q13164: TM-score 0.98, RMSD 1.16 Å
- 4B99 chain A against the predicted model Q13164: TM-score 0.97, RMSD 1.29 Å
- 4B99 chain A against the predicted model Q13164: TM-score 0.97, RMSD 1.29 Å
- 5O7I chain A against the predicted model Q13164: TM-score 0.97, RMSD 1.56 Å
- 5O7I chain A against the predicted model Q13164: TM-score 0.97, RMSD 1.56 Å
Elsewhere
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