Research workbench
Crystal structure of nak channel D66E mutant
Analyse Crystal structure of nak channel D66E mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Q6A
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel protein
- UniProt
- Q81HW2
- Ligands
- NA, CA
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium channel protein | protein | 104 | 78% helix, 0% strand | Q81HW2 |
| B | Potassium channel protein | protein | 103 | 78% helix, 0% strand | Q81HW2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.73 | 0.79 | 56 | empty |
| 2 | 60 | 0.35 | 0.77 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 1212 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2Q6A · Crystal Structure of Nak channel D66E mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81HW2
- Elsewhere: RCSB PDB 2Q6A · PDBe 2Q6A · UniProt Q81HW2
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