Research workbench
Crystal structure of human importin beta bound to the SNURPORTIN1 ibb- domain second crystal form
Analyse Crystal structure of human importin beta bound to the SNURPORTIN1 ibb- domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Q5D
- Type
- protein
- Length
- 1,775 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin beta-1 subunit; Snurportin-1
- UniProt
- Q14974, O95149
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin beta-1 subunit | protein | 871 | 72% helix, 0% strand | Q14974 |
| C | Snurportin-1 | protein | 36 | 67% helix, 0% strand | O95149 |
| B | Importin beta-1 subunit | protein | 845 | 64% helix, 0% strand | Q14974 |
| D | Snurportin-1 | protein | 23 | 91% helix, 0% strand | O95149 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 890 | 0.82 | 0.84 | 97 | empty |
| 2 | 356 | 0.80 | 0.89 | 41 | empty |
| 3 | 678 | 0.72 | 0.79 | 70 | empty |
| 4 | 536 | 0.68 | 0.78 | 76 | empty |
| 5 | 442 | 0.66 | 0.79 | 34 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1941 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1299 Ų buried · 22 hydrogen bonds · protein-protein
- B–D · 416 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2Q5D · Crystal Structure of Human Importin Beta bound to the Snurportin1 IBB-domain second… · the same entry in another collection · chain D against D, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.93
- O95149 · AlphaFold monomer V2.0 prediction for snurportin-1 (O95149) · a predicted model of the same protein · chain C against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt O95149
- Elsewhere: RCSB PDB 2Q5D · PDBe 2Q5D · UniProt Q14974 · UniProt O95149
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