Research workbench
DNA methyltransferase 3 like protein (DNMT3L)
Analyse DNA methyltransferase 3 like protein (DNMT3L) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PV0
- Type
- protein
- Length
- 1,041 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (cytosine-5)-methyltransferase 3-like
- UniProt
- Q9UJW3
- Ligands
- ZN
- Pockets
- 16 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C | DNA (cytosine-5)-methyltransferase 3-like | protein | 347 | 30% helix, 12% strand | Q9UJW3 |
Ligands and binding sites
- ZN · Zinc ion · metal · 9 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.83 | 0.84 | 99 | empty |
| 2 | 489 | 0.77 | 0.85 | 67 | empty |
| 3 | 884 | 0.74 | 0.78 | 86 | empty |
| 4 | 212 | 0.73 | 0.89 | 52 | empty |
| 5 | 55 | 0.70 | 0.97 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–C · 742 Ų buried · 4 hydrogen bonds · protein-protein
- B–A · 666 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJW3
- Elsewhere: RCSB PDB 2PV0 · PDBe 2PV0 · UniProt Q9UJW3
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