Research workbench
Crystal structure of activated porcine pancreatic carboxypeptidase B 2-(3-guanidino-phenyl)-3-[hydroxy-(3- phenyl-propyl)-phosphinoyl]-propionic acid complex
Analyse Crystal structure of activated porcine pancreatic carboxypeptidase B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PIZ
- Type
- protein
- Length
- 914 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carboxypeptidase B
- EC
- 3.4.17.2
- UniProt
- P09955
- Ligands
- 606, ZN
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Carboxypeptidase B (EC 3.4.17.2) | protein | 305 | 38% helix, 17% strand | P09955 |
| B | Carboxypeptidase B (EC 3.4.17.2) | protein | 304 | 38% helix, 18% strand | P09955 |
Ligands and binding sites
- 606 · (2S)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-[(S)-hydroxy(3-phenylpropyl)phosphoryl]propanoic acid · ligand · 3 copies · chains A, B, C
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 213 | 0.68 | 0.86 | 29 | 606 |
| 2 | 175 | 0.67 | 0.87 | 26 | 606 |
| 3 | 146 | 0.64 | 0.87 | 25 | 606 |
| 4 | 322 | 0.55 | 0.75 | 33 | empty |
| 5 | 69 | 0.42 | 0.80 | 20 | empty |
Interfaces
2 interfaces between chains.
- A–B · 463 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 189 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09955
- Elsewhere: RCSB PDB 2PIZ · PDBe 2PIZ · UniProt P09955
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.