UniProt P09955
Carboxypeptidase B (P09955)
Carboxypeptidase B (UniProt P09955), EC 3.4.17.2: 80 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09955
- Protein
- Carboxypeptidase B
- EC
- 3.4.17.2
- Experimental structures
- 80
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 13 · 5 records with a druggable one
Structures
81 records of P09955 in the MolNFT archive: 80 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NSA | Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity | x-ray diffraction | A | — | — |
| 1NSA | Three-dimensional structure of porcine procarboxypeptidase B: a structural basis of its inactivity | x-ray diffraction | A | — | — |
| 1PBA | The NMR structure of the activation domain isolated from porcine procarboxypeptidase B | solution nmr | A | — | — |
| 1PBA | The NMR structure of the activation domain isolated from porcine procarboxypeptidase B | solution nmr | A | — | — |
| 1Z5R | Crystal Structure of Activated Porcine Pancreatic Carboxypeptidase B | x-ray diffraction | A, B, C | — | — |
| 1Z5R | Crystal structure of activated porcine pancreatic carboxypeptidase B | x-ray diffraction | A, B, C | — | — |
| 1ZG7 | Crystal Structure of 2-(5-{[amino(imino)methyl]amino}-2-chlorophenyl)-3-sulfanylpropanoic acid… | x-ray diffraction | A, B, C | — | — |
| 1ZG7 | Crystal structure of 2-(5-{[AMINO(IMINO)METHYL]AMINO}-2- chlorophenyl)-3-sulfanylpropanoic acid… | x-ray diffraction | A, B, C | — | — |
| 1ZG8 | Crystal Structure of (R)-2-(3-{[amino(imino)methyl]amino}phenyl)-3-sulfanylpropanoic acid Bound to… | x-ray diffraction | A, B, C | — | — |
| 1ZG8 | Crystal structure of (R)-2-(3-{[AMINO(IMINO) METHYL]AMINO}PHENYL)-3-sulfanylpropanoic acid bound to… | x-ray diffraction | A, B, C | — | — |
| 1ZG9 | Crystal Structure of 5-{[amino(imino)methyl]amino}-2-(sulfanylmethyl)pentanoic acid Bound to… | x-ray diffraction | A, B, C | — | — |
| 1ZG9 | Crystal structure of 5-{[AMINO(IMINO)METHYL]AMINO}-2- (SULFANYLMETHYL)PENTANOIC acid bound to… | x-ray diffraction | A, B, C | — | — |
| 2JEW | Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid)… | x-ray diffraction | A | — | — |
| 2JEW | Crystal structure of ((2S)-5-amino-2-((1-N-propyl-1H-imidazol-4-yl) METHYL)PENTANOIC acid)… | x-ray diffraction | A | — | — |
| 2PIY | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PIY | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PIZ | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PIZ | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ0 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ0 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ1 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ1 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ2 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ2 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ3 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ3 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ4 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B | — | — |
| 2PJ4 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B | — | — |
| 2PJ5 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ5 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ6 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A | — | — |
| 2PJ6 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A | — | — |
| 2PJ7 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ7 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ8 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJ8 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJ9 | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A | — | — |
| 2PJ9 | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A | — | — |
| 2PJA | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJA | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJB | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJB | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 2PJC | CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B… | x-ray diffraction | A, B, C | — | — |
| 2PJC | Crystal structure of activated porcine pancreatic carboxypeptidase B… | x-ray diffraction | A, B, C | — | — |
| 3GLJ | A polymorph of carboxypeptidase B zymogen structure | x-ray diffraction | A | — | — |
| 3GLJ | A polymorph of carboxypeptidase B zymogen structure | x-ray diffraction | A | — | — |
| 3WAB | Carboxypeptidase B in complex with DD2 | x-ray diffraction | A | — | — |
| 3WAB | Carboxypeptidase B in complex with DD2 | x-ray diffraction | A | — | — |
| 3WC5 | Carboxypeptidase B in complex with DD9 | x-ray diffraction | A | — | — |
| 3WC5 | Carboxypeptidase B in complex with DD9 | x-ray diffraction | A | — | — |
| 3WC6 | Carboxypeptidase B in complex with 2nd zinc | x-ray diffraction | A | — | — |
| 3WC6 | Carboxypeptidase B in complex with 2ND zinc | x-ray diffraction | A | — | — |
| 3WC7 | Carboxypeptidase B in complex with EF6265 | x-ray diffraction | A | — | — |
| 3WC7 | Carboxypeptidase B in complex with EF6265 | x-ray diffraction | A | — | — |
| 4UIA | Crystal structure of 3a in complex with tafCPB | x-ray diffraction | A | — | — |
| 4UIA | Crystal structure of 3A in complex with tafcpb | x-ray diffraction | A | — | — |
| 4UIB | Crystal structure of 3p in complex with tafCPB | x-ray diffraction | A | — | — |
| 4UIB | Crystal structure of 3P in complex with tafcpb | x-ray diffraction | A | — | — |
| 4Z65 | Carboxypeptidase B with Sulphamoil Arginine | x-ray diffraction | A | ZN, 0X9 | 1 (best 0.61) |
| 4Z65 | Carboxypeptidase B with sulphamoil arginine | x-ray diffraction | A | — | — |
21 records more on the page itself.
Ligands
- ZN · Zinc ion · in 19 records
- 73O · (2~{S})-2-azanyl-4-(4-hydroxyphenyl)butanoic acid · in 3 records
- 73N · (2~{S})-5-carbamimidamido-2-(carboxyamino)pentanoic acid · in 2 records
- 7B0 · (2~{S})-6-azanyl-2-(sulfamoylamino)hexanoic acid · in 2 records
- 7B6 · (2~{S})-6-azanyl-2-[[(2~{R})-1-[[(1~{R},2~{S},4~{S})-2-bicyclo[2.2.1]heptanyl]amino]-3-cyclohexyl-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid · in 2 records
- 9B3 · (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid · in 2 records
- T4F · (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid · in 2 records
- T5F · (2~{S})-2-[[(2~{S})-1-(1-adamantylamino)-3-cyclohexyl-1-oxidanylidene-propan-2-yl]sulfamoylamino]-6-azanyl-hexanoic acid · in 2 records
- 0X9 · N~2~-sulfamoyl-L-arginine · in 1 record
- 73P · (2~{S})-6-azanyl-2-(carboxyamino)hexanoic acid · in 1 record
- CXA · Phenylalanine-N-sulfonamide · in 1 record
Experiment against prediction
- 5LRJ chain A against the predicted model P09955: TM-score 1.00, RMSD 0.34 Å
- 5LRJ chain A against the predicted model P09955: TM-score 1.00, RMSD 0.34 Å
- 5J1Q chain A against the predicted model P09955: TM-score 1.00, RMSD 0.35 Å
- 5J1Q chain A against the predicted model P09955: TM-score 1.00, RMSD 0.35 Å
- 5LRJ chain B against the predicted model P09955: TM-score 1.00, RMSD 0.35 Å
- 5LRJ chain B against the predicted model P09955: TM-score 1.00, RMSD 0.35 Å
- 3WC6 chain A against the predicted model P09955: TM-score 1.00, RMSD 0.36 Å
- 3WC6 chain A against the predicted model P09955: TM-score 1.00, RMSD 0.36 Å
- 5ZEQ chain A against the predicted model P09955: TM-score 1.00, RMSD 0.36 Å
- 5ZEQ chain A against the predicted model P09955: TM-score 1.00, RMSD 0.36 Å
Elsewhere
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