Research workbench
The NMR structure of the 38KDA U1A protein-pie RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein
Analyse The NMR structure of the 38KDA U1A protein-pie RNA complex reveals the basis of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DZ5
- Type
- protein + RNA
- Length
- 246 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U1 small nuclear ribonucleoprotein a; Pie, RNA…
- UniProt
- P09012
- Pockets
- 2 · best druggability 0.74
Structure
solution nmr · 2 distinct chains · 26% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | U1 small nuclear ribonucleoprotein a | protein | 101 | 26% helix, 22% strand | P09012 |
| C, D | Pie, RNA (5'-R(*GP*AP*GP*AP*CP*AP*UP*UP*GP*CP*AP*CP*CP* CP*GP*GP*AP*GP*UP*CP*UP*C)-3') | rna | 22 | — | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1199 | 0.74 | 0.77 | 65 | empty |
| 2 | 246 | 0.57 | 0.79 | 26 | empty |
Interfaces
6 interfaces between chains.
- C–D · 777 Ų buried · 76 hydrogen bonds · nucleic-nucleic
- A–D · 772 Ų buried · 29 hydrogen bonds · protein-nucleic
- B–C · 771 Ų buried · 30 hydrogen bonds · protein-nucleic
- A–B · 522 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 192 Ų buried · 4 hydrogen bonds · protein-nucleic
Compared structures
- 1DZ5 · The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09012
- Elsewhere: RCSB PDB 1DZ5 · PDBe 1DZ5 · UniProt P09012
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.