Research workbench

Estrogen related receptor gamma in complex with 4-hydroxy- tamoxifen

Analyse Estrogen related receptor gamma in complex with 4-hydroxy- tamoxifen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2P7Z
Type: protein
Length: 207 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Estrogen-related receptor gamma
UniProt: P62508
Ligands: OHT
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 68% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Estrogen-related receptor gamma	protein	207	68% helix, 3% strand	P62508

Ligands and binding sites

OHT · 4-hydroxytamoxifen · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	243	0.80	0.92	25	OHT
2	164	0.68	0.87	23	empty

Compared structures

2P7Z · Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen · the same entry in another collection · chain A against A, TM-score 1.00
P62508 · AlphaFold monomer V2.0 prediction for estrogen-related receptor gamma (P62508) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62508
Elsewhere: RCSB PDB 2P7Z · PDBe 2P7Z · UniProt P62508

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