Research workbench
Complex of a camelid single-domain vhh antibody fragment with RNase a at 2.5A resolution: SE5B-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold.
Analyse Complex of a camelid single-domain vhh antibody fragment with RNase a at 2.5A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2P46
- Type
- protein
- Length
- 482 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease pancreatic; Antibody cab-RN05
- EC
- 3.1.27.5
- UniProt
- P61823
- Ligands
- ZN
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ribonuclease pancreatic (EC 3.1.27.5) | protein | 120 | 22% helix, 37% strand | P61823 |
| B, D | Antibody cab-RN05 | protein | 121 | 7% helix, 50% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 11 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
3 interfaces between chains.
- B–D · 671 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 651 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 640 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 10 modified (disulfide, engineered).
Compared structures
- 2P46 · Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61823
- Elsewhere: RCSB PDB 2P46 · PDBe 2P46 · UniProt P61823
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