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Crystal structure of human nucleophosmin-core
Analyse Crystal structure of human nucleophosmin-core in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2P1B
- Type
- protein
- Length
- 1,000 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleophosmin
- UniProt
- P06748
- Pockets
- 5 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 61% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Nucleophosmin | protein | 100 | 0% helix, 61% strand | P06748 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1085 | 0.88 | 0.89 | 111 | empty |
| 2 | 120 | 0.55 | 0.83 | 22 | empty |
| 3 | 59 | 0.33 | 0.76 | 15 | empty |
| 4 | 50 | 0.31 | 0.76 | 16 | empty |
| 5 | 51 | 0.31 | 0.76 | 15 | empty |
Interfaces
15 interfaces between chains.
- F–G · 1018 Ų buried · 16 hydrogen bonds · protein-protein
- I–J · 1017 Ų buried · 19 hydrogen bonds · protein-protein
- G–H · 1015 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 1013 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1005 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06748
- Elsewhere: RCSB PDB 2P1B · PDBe 2P1B · UniProt P06748
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