Research workbench
Karyopherin BETA2/TRANSPORTIN-hnrnpm nls complex
Analyse Karyopherin BETA2/TRANSPORTIN-hnrnpm nls complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OT8
- Type
- protein
- Length
- 1,674 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; Heterogeneous nuclear ribonucleoprotein M
- UniProt
- Q92973, P52272
- Pockets
- 20 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 824 | 77% helix, 0% strand | Q92973 |
| B | Transportin-1 | protein | 813 | 77% helix, 0% strand | Q92973 |
| C | Heterogeneous nuclear ribonucleoprotein M | protein | 17 | 0% helix, 0% strand | P52272 |
| D | Heterogeneous nuclear ribonucleoprotein M | protein | 20 | 0% helix, 0% strand | P52272 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.67 | 0.93 | 17 | empty |
| 2 | 340 | 0.60 | 0.77 | 28 | empty |
| 3 | 288 | 0.56 | 0.77 | 40 | empty |
| 4 | 206 | 0.56 | 0.79 | 36 | empty |
| 5 | 208 | 0.56 | 0.79 | 24 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1379 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 1232 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 816 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2OT8 · Karyopherin Beta2/Transportin-hnRNPM NLS Complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P52272 · AlphaFold monomer V2.0 prediction for heterogeneous nuclear ribonucleoprotein M (P52272) · a predicted model of the same protein · chain C against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P52272
- Elsewhere: RCSB PDB 2OT8 · PDBe 2OT8 · UniProt Q92973 · UniProt P52272
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