Research workbench
Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a C-terminal peptide of wiskott-aldrich syndrome protein
Analyse Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OT0
- Type
- protein
- Length
- 1,427 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-bisphosphate aldolase a; Wiskott-aldrich syndrome protein C-terminal peptide
- EC
- 4.1.2.13
- UniProt
- P00883, P42768
- Pockets
- 14 · best druggability 0.89
Structure
x-ray diffraction · 4 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-bisphosphate aldolase a (EC 4.1.2.13) | protein | 356 | 47% helix, 15% strand | P00883 |
| B | Fructose-bisphosphate aldolase a (EC 4.1.2.13) | protein | 357 | 47% helix, 15% strand | P00883 |
| C, D | Fructose-bisphosphate aldolase a (EC 4.1.2.13) | protein | 349 | 46% helix, 15% strand | P00883 |
| E, F, G, H | Wiskott-aldrich syndrome protein C-terminal peptide | protein | 4 | 0% helix, 0% strand | P42768 |
Pockets
14 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1059 | 0.89 | 0.90 | 111 | empty |
| 2 | 668 | 0.80 | 0.85 | 83 | empty |
| 3 | 801 | 0.79 | 0.82 | 109 | empty |
| 4 | 150 | 0.65 | 0.87 | 48 | empty |
| 5 | 150 | 0.64 | 0.86 | 45 | empty |
Interfaces
10 interfaces between chains.
- A–D · 1447 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 1354 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1233 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1217 Ų buried · 17 hydrogen bonds · protein-protein
- A–E · 454 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2OT0 · Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a C-terminal… · the same entry in another collection · chain H against H, TM-score 1.00
- P00883 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P00883) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00883
- Every structure of UniProt P42768
- Elsewhere: RCSB PDB 2OT0 · PDBe 2OT0 · UniProt P00883 · UniProt P42768
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