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The crystal structure of the 10TH PDZ domain of mpdz

Analyse The crystal structure of the 10TH PDZ domain of mpdz in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2OPG
Type: protein
Length: 196 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multiple PDZ domain protein
UniProt: O75970
Ligands: NA
Pockets: 1 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Multiple PDZ domain protein	protein	98	14% helix, 40% strand	O75970

Ligands and binding sites

NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.63	0.85	24	empty

Interfaces

1 interface between chains.

A–B · 1266 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2OPG · The crystal structure of the 10th PDZ domain of MPDZ · the same entry in another collection · chain A against A, TM-score 1.00
O75970 · AlphaFold monomer V2.0 prediction for multiple PDZ domain protein (O75970) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75970
Elsewhere: RCSB PDB 2OPG · PDBe 2OPG · UniProt O75970

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