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Hepatitis delta virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation tl+

Analyse Hepatitis delta virus gemonic ribozyme precursor with C75U mutation and bound… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2OIH
Type: protein + RNA
Length: 168 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hdv ribozyme; U1 small nuclear ribonucleoprotein a
UniProt: P09012
Ligands: TL
Pockets: 4 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Hdv ribozyme	rna	73	—	—
A	U1 small nuclear ribonucleoprotein a	protein	95	32% helix, 24% strand	P09012

Ligands and binding sites

TL · Thallium (I) ion · metal · 15 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	377	0.66	0.80	36	TL
2	484	0.58	0.74	28	TL
3	284	0.48	0.74	17	TL
4	86	0.40	0.79	13	TL

Interfaces

1 interface between chains.

B–A · 1005 Å² buried · 37 hydrogen bonds · protein-nucleic

Compared structures

2OIH · Hepatitis Delta Virus gemonic ribozyme precursor with C75U mutation and bound to… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09012
Elsewhere: RCSB PDB 2OIH · PDBe 2OIH · UniProt P09012

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