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Crystal structure of the autoinhibited human C-fms kinase domain

Analyse Crystal structure of the autoinhibited human C-fms kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2OGV
Type: protein
Length: 317 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage colony-stimulating factor 1 receptor precursor
EC: 2.7.10.1
UniProt: P07333
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1)	protein	317	36% helix, 20% strand	P07333

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.66	0.90	34	empty
2	128	0.57	0.83	22	empty
3	57	0.38	0.80	16	empty

Compared structures

2OGV · Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain · the same entry in another collection · chain A against A, TM-score 1.00
P07333 · AlphaFold monomer V2.0 prediction for macrophage colony-stimulating factor 1 receptor… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07333
Elsewhere: RCSB PDB 2OGV · PDBe 2OGV · UniProt P07333

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