Research workbench
Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product
Analyse Crystal structure of the human S-adenosylmethionine synthetase 1 in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OBV
- Type
- protein
- Length
- 384 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-adenosylmethionine synthetase isoform type-1
- EC
- 2.5.1.6
- UniProt
- Q00266
- Ligands
- SAM, NA
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-adenosylmethionine synthetase isoform type-1 (EC 2.5.1.6) | protein | 384 | 34% helix, 26% strand | Q00266 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- PG4 · Tetraethylene glycol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.33 | 0.77 | 14 | empty |
Compared structures
- 2OBV · Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q00266 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00266
- Elsewhere: RCSB PDB 2OBV · PDBe 2OBV · UniProt Q00266
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