UniProt Q00266
S-adenosylmethionine synthase isoform type-1 (Q00266)
S-adenosylmethionine synthase isoform type-1 (UniProt Q00266), EC 2.5.1.6: 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q00266
- Protein
- S-adenosylmethionine synthase isoform type-1
- EC
- 2.5.1.6
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 22 · 2 records with a druggable one
Structures
8 records of Q00266 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OBV | Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product | x-ray diffraction | A | — | — |
| 2OBV | Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product | x-ray diffraction | A | — | — |
| 6SW5 | Crystal structure of the human S-adenosylmethionine synthetase 1 (ligand-free form) | x-ray diffraction | A, B, C, D | — | 14 (best 0.81) |
| 6SW5 | Crystal structure of the human S-adenosylmethionine synthetase 1 (ligand-free form) | x-ray diffraction | A, B, C, D | — | — |
| 6SW6 | Crystal structure R264H mutant of the human S-adenosylmethionine synthetase 1 | x-ray diffraction | A, B | — | 7 (best 0.73) |
| 6SW6 | Crystal structure R264H mutant of the human S-adenosylmethionine synthetase 1 | x-ray diffraction | A, B | — | — |
| 8SWA | Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP | x-ray diffraction | A | PPK, MG, K, SAM | 1 (best 0.33) |
| Q00266 | AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-1 (Q00266) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8SWA chain A against the predicted model Q00266: TM-score 1.00, RMSD 0.26 Å
- 6SW6 chain B against the predicted model Q00266: TM-score 0.99, RMSD 0.73 Å
- 6SW6 chain B against the predicted model Q00266: TM-score 0.99, RMSD 0.73 Å
- 2OBV chain A against the predicted model Q00266: TM-score 0.99, RMSD 0.82 Å
- 2OBV chain A against the predicted model Q00266: TM-score 0.99, RMSD 0.82 Å
- 6SW5 chain A against the predicted model Q00266: TM-score 0.98, RMSD 1.36 Å
- 6SW5 chain A against the predicted model Q00266: TM-score 0.98, RMSD 1.36 Å
- 6SW5 chain B against the predicted model Q00266: TM-score 0.98, RMSD 1.39 Å
- 6SW5 chain B against the predicted model Q00266: TM-score 0.98, RMSD 1.39 Å
- 6SW5 chain C against the predicted model Q00266: TM-score 0.98, RMSD 1.35 Å
Elsewhere
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