MolNFT v1 · #164391 · protein
Crystal structure R264H mutant of the human S-adenosylmethionine synthetase 1
6SW6 · S-adenosylmethionine synthase isoform type-1: “Crystal structure R264H mutant of the human S-adenosylmethionine synthetase 1”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #164391 on GenesisL1: 3D structure…
- PDB
- 6SW6
- Type
- protein
- Length
- 739 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-adenosylmethionine synthase isoform type-1
- EC
- 2.5.1.6
- UniProt
- Q00266
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-adenosylmethionine synthase isoform type-1 (EC 2.5.1.6) | protein | 382 | 31% helix, 25% strand | Q00266 |
| B | S-adenosylmethionine synthase isoform type-1 (EC 2.5.1.6) | protein | 357 | 32% helix, 26% strand | Q00266 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 433 | 0.73 | 0.83 | 40 | empty |
| 2 | 648 | 0.72 | 0.80 | 82 | empty |
| 3 | 513 | 0.70 | 0.80 | 46 | empty |
| 4 | 69 | 0.35 | 0.77 | 18 | empty |
| 5 | 51 | 0.34 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2409 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 6SW6 · Crystal structure R264H mutant of the human S-adenosylmethionine synthetase 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q00266 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-1… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00266
- Elsewhere: RCSB PDB 6SW6 · PDBe 6SW6 · UniProt Q00266
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