Research workbench
Crystal structure of the metal-free dimeric human MOV34 mpn domain (residues 1-177)
Analyse Crystal structure of the metal-free dimeric human MOV34 mpn domain (residues… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2O96
- Type
- protein
- Length
- 319 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome non-ATPase regulatory subunit 7
- UniProt
- P51665
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome non-ATPase regulatory subunit 7 | protein | 158 | 22% helix, 35% strand | P51665 |
| B | 26S proteasome non-ATPase regulatory subunit 7 | protein | 161 | 22% helix, 34% strand | P51665 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.81 | 0.97 | 37 | empty |
| 2 | 373 | 0.55 | 0.74 | 53 | empty |
| 3 | 92 | 0.40 | 0.77 | 19 | empty |
| 4 | 103 | 0.39 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1125 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2O96 · Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-177) · the same entry in another collection · chain A against A, TM-score 1.00
- P51665 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 7… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51665
- Elsewhere: RCSB PDB 2O96 · PDBe 2O96 · UniProt P51665
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