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Structure of middle plus C-terminal domains (M+C) of GRP94

Analyse Structure of middle plus C-terminal domains (M+C) of GRP94 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2O1T
Type: protein
Length: 4,130 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoplasmin
UniProt: P41148
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Endoplasmin	protein	413	44% helix, 17% strand	P41148

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1115	0.80	0.81	109	empty
2	1138	0.80	0.81	108	empty
3	1017	0.79	0.81	89	empty
4	1124	0.79	0.81	94	empty
5	813	0.79	0.82	77	empty

Interfaces

16 interfaces between chains.

F–G · 2408 Å² buried · 22 hydrogen bonds · protein-protein
D–E · 2337 Å² buried · 13 hydrogen bonds · protein-protein
A–J · 2310 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 2220 Å² buried · 12 hydrogen bonds · protein-protein
H–I · 2215 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

2O1T · Structure of Middle plus C-terminal domains (M+C) of GRP94 · the same entry in another collection · chain J against J, TM-score 1.00
P41148 · AlphaFold monomer V2.0 prediction for endoplasmin (P41148) · a predicted model of the same protein · chain C against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41148
Elsewhere: RCSB PDB 2O1T · PDBe 2O1T · UniProt P41148

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