UniProt P41148
Endoplasmin (P41148)
Endoplasmin (UniProt P41148): 65 experimental structures and 1 predicted model on GenesisL1, 19 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41148
- Protein
- Endoplasmin
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 19
- Pockets
- 5 · 1 record with a druggable one
Structures
66 records of P41148 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QY8 | Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with Radicicol | x-ray diffraction | A | — | — |
| 1QY8 | Crystal structure of the N-domain of the er HSP90 chaperone GRP94 in complex with radicicol | x-ray diffraction | A | — | — |
| 1QYE | Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with… | x-ray diffraction | A | — | — |
| 1QYE | Crystal structure of the N-domain of the er HSP90 chaperone GRP94 in complex with… | x-ray diffraction | A | — | — |
| 1TBW | Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation | x-ray diffraction | A, B | — | — |
| 1TBW | Ligand induced conformational shift in the N-terminal domain of GRP94, open conformation | x-ray diffraction | A, B | — | — |
| 1TC0 | Ligand Induced Conformational Shifts in the N-terminal Domain of GRP94, Open Conformation Complexed… | x-ray diffraction | A, B | — | — |
| 1TC0 | Ligand induced conformational shifts in the N-terminal domain of GRP94, open conformation complexed… | x-ray diffraction | A, B | — | — |
| 1TC6 | Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation ADP-Complex | x-ray diffraction | A, B | — | — |
| 1TC6 | Ligand induced conformational shift in the N-terminal domain of GRP94, open conformation ADP-complex | x-ray diffraction | A, B | — | — |
| 1U0Z | N-Domain Of Grp94 Lacking The Charged Domain In Complex With Radicicol | x-ray diffraction | A, B | — | — |
| 1U0Z | N-domain of GRP94 lacking the charged domain in complex with radicicol | x-ray diffraction | A, B | — | — |
| 1U2O | Crystal Structure Of The N-Domain Of Grp94 Lacking The Charged Domain In Complex With Neca | x-ray diffraction | A, B | — | — |
| 1U2O | Crystal structure of the N-domain of GRP94 lacking the charged domain in complex with neca | x-ray diffraction | A, B | — | — |
| 1YSZ | Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced… | x-ray diffraction | A | — | — |
| 1YSZ | Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced… | x-ray diffraction | A | — | — |
| 1YT0 | Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced… | x-ray diffraction | A | — | — |
| 1YT0 | Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced… | x-ray diffraction | A | — | — |
| 1YT1 | Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced… | x-ray diffraction | A, B | — | — |
| 1YT1 | Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced… | x-ray diffraction | A, B | — | — |
| 1YT2 | Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced… | x-ray diffraction | A | — | — |
| 1YT2 | Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced… | x-ray diffraction | A | — | — |
| 2ESA | GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA | x-ray diffraction | A | — | — |
| 2ESA | GRP94 N-terminal domain bound to geldanamycin: effects of mutants 168- 169 ks-aa | x-ray diffraction | A | — | — |
| 2EXL | GRP94 N-terminal Domain bound to geldanamycin | x-ray diffraction | A, B | — | — |
| 2EXL | GRP94 N-terminal domain bound to geldanamycin | x-ray diffraction | A, B | — | — |
| 2FYP | GRP94 in complex with the novel HSP90 Inhibitor Radester amine | x-ray diffraction | A, B | — | — |
| 2FYP | GRP94 in complex with the novel HSP90 inhibitor radester amine | x-ray diffraction | A, B | — | — |
| 2GFD | GRP94 in complex with the novel HSP90 Inhibitor Radamide | x-ray diffraction | A, B | — | — |
| 2GFD | GRP94 in complex with the novel HSP90 inhibitor radamide | x-ray diffraction | A, B | — | — |
| 2GQP | N-Domain Of Grp94 In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine | x-ray diffraction | A, B | — | — |
| 2GQP | N-domain of GRP94 in complex with the novel ligand N-propyl carboxyamido adenosine | x-ray diffraction | A, B | — | — |
| 2H8M | N-Domain Of Grp94 In Complex With the 2-Iodo-NECA | x-ray diffraction | A, B | — | — |
| 2H8M | N-domain of GRP94 in complex with the 2-iodo-neca | x-ray diffraction | A, B | — | — |
| 2HCH | N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-amino)ethyl Carboxyamido Adenosine | x-ray diffraction | A, B | — | — |
| 2HCH | N-domain of GRP94 in complex with the novel ligand N-(2-AMINO)ETHYL carboxyamido adenosine | x-ray diffraction | A, B | — | — |
| 2HG1 | N-Domain Of Grp94 In Complex With the Novel Ligand N-(2-hydroxyl)ethyl Carboxyamido Adenosine | x-ray diffraction | A, B | — | — |
| 2HG1 | N-domain of GRP94 in complex with the novel ligand N-(2- HYDROXYL)ETHYL carboxyamido adenosine | x-ray diffraction | A, B | — | — |
| 2O1T | Structure of Middle plus C-terminal domains (M+C) of GRP94 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2O1T | Structure of middle plus C-terminal domains (M+C) of GRP94 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2O1U | Structure of full length GRP94 with AMP-PNP bound | x-ray diffraction | A, B | — | — |
| 2O1U | Structure of full length GRP94 with AMP-pnp bound | x-ray diffraction | A, B | — | — |
| 2O1V | Structure of full length GRP94 with ADP bound | x-ray diffraction | A, B | — | — |
| 2O1V | Structure of full length GRP94 with ADP bound | x-ray diffraction | A, B | — | — |
| 2O1W | Structure of N-terminal plus middle domains (N+M) of GRP94 | x-ray diffraction | A, B, C, D, E | — | — |
| 2O1W | Structure of N-terminal plus middle domains (N+M) of GRP94 | x-ray diffraction | A, B, C, D, E | — | — |
| 3O2F | Structure of the N-domain of GRP94 bound to the HSP90 inhibitor PU-H54 | x-ray diffraction | A, B | — | — |
| 3O2F | Structure of the N-domain of GRP94 bound to the HSP90 inhibitor pu-H54 | x-ray diffraction | A, B | — | — |
| 5IN9 | Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol… | x-ray diffraction | A, B | 6C0 | — |
| 5IN9 | Crystal structure of GRP94 bound to methyl 3-chloro-2-(2-(1-((5… | x-ray diffraction | A, B | — | — |
| 5TTZ | Crystal structure of Grp94 bound to isoform-selective inhibitor methyl… | x-ray diffraction | A, B | 7KY | — |
| 5TTZ | Crystal structure of GRP94 bound to isoform-selective inhibitor methyl… | x-ray diffraction | A, B | 7KY | — |
| 5ULS | Structure of GRP94 in the active conformation | x-ray diffraction | A, B | ANP | — |
| 5WMT | Structure of GRP94 N-terminal domain bound to resorcinylic inhibitor bnim. | x-ray diffraction | A, B, C, D | 9QY, MG | — |
| 6AOL | Structure of molecular chaperone GRP94 bound to selective inhibitor methyl… | x-ray diffraction | A | VC1 | — |
| 6AOM | Structure of molecular chaperone Grp94 bound to selective inhibitor methyl… | x-ray diffraction | A, B | VC5 | — |
| 6AOM | Structure of molecular chaperone GRP94 bound to selective inhibitor methyl… | x-ray diffraction | A, B | VC5 | — |
| 6ASP | Structure of GRP94 with methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H… | x-ray diffraction | A, B | V2C | — |
| 6ASQ | Structure of GRP94 bound to methyl 2-[2-(2-benzylpyridin-3-YL)ETHYL]… | x-ray diffraction | A, B | VC4 | — |
| 6BAW | Structure of GRP94 with a selective resorcinylic inhibitor. | x-ray diffraction | B, A, C, D | D57, PO4 | — |
6 records more on the page itself.
Ligands
- 7KY · methyl 2-(2-{1-[(4-bromophenyl)methyl]-1H-imidazol-2-yl}ethyl)-3-chloro-4,6-dihydroxybenzoate · in 2 records
- MG · Magnesium ion · in 2 records
- VC5 · methyl 2-[2-(2-benzylphenyl)ethyl]-3-chloro-4,6-dihydroxybenzoate · in 2 records
- 6C0 · methyl 3-chloro-2-(2-{1-[(5-chlorofuran-2-yl)methyl]-1H-imidazol-2-yl}ethyl)-4,6-dihydroxybenzoate · in 1 record
- 9QY · Methyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- CA · Calcium ion · in 1 record
- D57 · dimethyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-4,6-dihydroxybenzene-1,3-dicarboxylate · in 1 record
- EQD · 5-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-4,6-dichlorobenzene-1,3-diol · in 1 record
- H71 · 8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-9-[3-(isopropylamino)propyl]-9H-purin-6-amine · in 1 record
- M2M · 1-methoxy-2-(2-methoxyethoxy)ethane · in 1 record
- N5O · 5'-N-(2-hydroxyl)ethyl carboxyamido adenosine · in 1 record
- NEC · N-ethyl-5'-carboxamido adenosine · in 1 record
- PA7 · N-propyl carboxyamido adenosine · in 1 record
- PO4 · Phosphate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- V2C · Methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate · in 1 record
- VC1 · Methyl 3-chloro-2-(2-{2-[(4-fluorophenyl) methyl]phenyl}ethyl)-4,6-dihydroxybenzoate · in 1 record
- VC4 · Methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate · in 1 record
Experiment against prediction
- 5ULS chain B against the predicted model P41148: TM-score 0.98, RMSD 1.20 Å
- 5ULS chain A against the predicted model P41148: TM-score 0.97, RMSD 1.75 Å
- 1YT0 chain A against the predicted model P41148: TM-score 0.93, RMSD 1.46 Å
- 1YT0 chain A against the predicted model P41148: TM-score 0.93, RMSD 1.46 Å
- 2O1T chain C against the predicted model P41148: TM-score 0.93, RMSD 2.02 Å
- 2O1T chain C against the predicted model P41148: TM-score 0.93, RMSD 2.02 Å
- 2O1T chain A against the predicted model P41148: TM-score 0.93, RMSD 2.03 Å
- 2O1T chain A against the predicted model P41148: TM-score 0.93, RMSD 2.03 Å
- 2O1T chain I against the predicted model P41148: TM-score 0.93, RMSD 2.03 Å
- 2O1T chain I against the predicted model P41148: TM-score 0.93, RMSD 2.03 Å
Elsewhere
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