Research workbench
Crystal structure of ALPHA1,3-fucosyltransferase with GDP
Analyse Crystal structure of ALPHA1,3-fucosyltransferase with GDP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2NZX
- Type
- protein
- Length
- 1,028 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALPHA1,3-fucosyltransferase
- EC
- 2.4.1.152
- UniProt
- O30511
- Ligands
- GDP, SO4
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ALPHA1,3-fucosyltransferase (EC 2.4.1.152) | protein | 340 | 37% helix, 16% strand | O30511 |
| B | ALPHA1,3-fucosyltransferase (EC 2.4.1.152) | protein | 338 | 37% helix, 17% strand | O30511 |
| C | ALPHA1,3-fucosyltransferase (EC 2.4.1.152) | protein | 350 | 39% helix, 15% strand | O30511 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 3 copies · chains A, B, C
- SO4 · Sulfate ion · ion · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.79 | 0.80 | 123 | empty |
| 2 | 541 | 0.71 | 0.80 | 46 | empty |
| 3 | 280 | 0.58 | 0.78 | 34 | empty |
| 4 | 174 | 0.55 | 0.80 | 29 | empty |
| 5 | 147 | 0.52 | 0.80 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–C · 817 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 672 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 366 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2NZX · Crystal Structure of alpha1,3-Fucosyltransferase with GDP · the same entry in another collection · chain A against A, TM-score 1.00
- O30511 · AlphaFold monomer V2.0 prediction for alpha-(1,3)-fucosyltransferase fuct (O30511) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O30511
- Elsewhere: RCSB PDB 2NZX · PDBe 2NZX · UniProt O30511
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