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The crystal structure of human eukaryotic release factor ERF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

Analyse The crystal structure of human eukaryotic release factor ERF1-mechanism of stop… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1DT9
Type: protein
Length: 398 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (eukaryotic peptide chain release factor subunit 1)
UniProt: P62495
Pockets: 2 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (eukaryotic peptide chain release factor subunit 1)	protein	398	32% helix, 18% strand	P62495

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	390	0.58	0.75	31	empty
2	138	0.39	0.73	21	empty

Compared structures

1DT9 · The crystal structure of human eukaryotic release factor ERF1-mechanism of stop codon… · the same entry in another collection · chain A against A, TM-score 1.00
P62495 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62495
Elsewhere: RCSB PDB 1DT9 · PDBe 1DT9 · UniProt P62495

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