UniProt P62495
Eukaryotic peptide chain release factor subunit 1 (P62495)
Eukaryotic peptide chain release factor subunit 1 (UniProt P62495): 32 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction…
- UniProt
- P62495
- Protein
- Eukaryotic peptide chain release factor subunit 1
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 1 · 1 record with a druggable one
Structures
33 records of P62495 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DT9 | The crystal structure of human eukaryotic release factor ERF1-mechanism of stop codon recognition… | x-ray diffraction | A | — | — |
| 1DT9 | The crystal structure of human eukaryotic release factor ERF1-mechanism of stop codon recognition… | x-ray diffraction | A | — | — |
| 2HST | Solution structure of the middle domain of human eukaryotic translation termination factor eRF1 | solution nmr | A | — | — |
| 2HST | Solution structure of the middle domain of human eukaryotic translation termination factor ERF1 | solution nmr | A | — | — |
| 2KTU | Human eRF1 C-domain, closed" conformer" | solution nmr | A | — | — |
| 2KTU | Human ERF1 C-domain, "closed" conformer | solution nmr | A | — | — |
| 2KTV | Human eRF1 C-domain, open" conformer" | solution nmr | A | — | — |
| 2KTV | Human ERF1 C-domain, "open" conformer | solution nmr | A | — | — |
| 2LGT | Backbone 1H, 13C, and 15N Chemical Shift Assignments for QFM(Y)F | solution nmr | A | — | — |
| 2LGT | Backbone 1H, 13C, and 15N chemical shift assignments for QFM(Y)F | solution nmr | A | — | — |
| 2LLX | Solution structure of the N-terminal domain of human polypeptide chain release factor eRF1 | solution nmr | A | — | — |
| 2LLX | Solution structure of the N-terminal domain of human polypeptide chain release factor ERF1 | solution nmr | A | — | — |
| 2MQ6 | Solution structure of Y125F mutant of eRF1 N-domain | solution nmr | A | — | — |
| 2MQ6 | Solution structure of Y125F mutant of ERF1 N-domain | solution nmr | A | — | — |
| 2MQ9 | Solution structure of E55Q mutant of eRF1 N-domain | solution nmr | A | — | — |
| 2MQ9 | Solution structure of E55Q mutant of ERF1 N-domain | solution nmr | A | — | — |
| 3E1Y | Crystal structure of human eRF1/eRF3 complex | x-ray diffraction | A, B, C, D | — | — |
| 3E1Y | Crystal structure of human ERF1/ERF3 complex | x-ray diffraction | A, B, C, D | — | — |
| 3J5Y | Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP | electron microscopy | A | — | — |
| 3J5Y | Structure of the mammalian ribosomal pre-termination complex associated with ERF1-ERF3-gdpnp | electron microscopy | A | — | — |
| 3JAG | Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon | electron microscopy | ii | — | — |
| 3JAH | Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon | electron microscopy | ii | — | — |
| 3JAI | Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon | electron microscopy | ii | — | — |
| 4D5N | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus… | electron microscopy | A | — | — |
| 4D5N | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus… | electron microscopy | A | — | — |
| 4D61 | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus… | electron microscopy | h | — | — |
| 4D61 | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus… | electron microscopy | h | — | — |
| 5A8L | Human eRF1 and the hCMV nascent peptide in the translation termination complex | electron microscopy | Q | — | — |
| 5A8L | Human ERF1 and the hcmv nascent peptide in the translation termination complex | electron microscopy | Q | — | — |
| 5LZV | Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1. | electron microscopy | ii | MG | — |
| 6IP8 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | electron microscopy | zw | — | — |
| 8SCB | Terminating ribosome with SRI-41315 | electron microscopy | ii | MG, ZVM | 1 (best 0.86) |
| P62495 | AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1 (P62495) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2LLX chain A against the predicted model P62495: TM-score 0.88, RMSD 1.68 Å
- 2LLX chain A against the predicted model P62495: TM-score 0.88, RMSD 1.68 Å
- 2MQ9 chain A against the predicted model P62495: TM-score 0.86, RMSD 1.96 Å
- 2MQ9 chain A against the predicted model P62495: TM-score 0.86, RMSD 1.96 Å
- 2LGT chain A against the predicted model P62495: TM-score 0.82, RMSD 2.30 Å
- 2LGT chain A against the predicted model P62495: TM-score 0.82, RMSD 2.30 Å
- 2KTV chain A against the predicted model P62495: TM-score 0.81, RMSD 2.09 Å
- 2KTV chain A against the predicted model P62495: TM-score 0.81, RMSD 2.09 Å
- 1DT9 chain A against the predicted model P62495: TM-score 0.81, RMSD 3.99 Å
- 1DT9 chain A against the predicted model P62495: TM-score 0.81, RMSD 3.99 Å
Elsewhere
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