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Holo form of calmodulin-like domain of human non-muscle alpha-actinin 1

Analyse Holo form of calmodulin-like domain of human non-muscle alpha-actinin 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2N8Y
Type: protein
Length: 153 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-actinin-1
UniProt: P12814
Ligands: CA
Pockets: 1 · best druggability 0.54

Structure

solution nmr · 1 distinct chain · 46% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-actinin-1	protein	153	46% helix, 7% strand	P12814

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	184	0.54	0.79	29	empty

Compared structures

2N8Y · Holo form of Calmodulin-Like Domain of Human Non-Muscle alpha-actinin 1 · the same entry in another collection · chain A against A, TM-score 1.00
P12814 · AlphaFold monomer V2.0 prediction for alpha-actinin-1 (P12814) · a predicted model of the same protein · chain A against A, TM-score 0.43

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12814
Elsewhere: RCSB PDB 2N8Y · PDBe 2N8Y · UniProt P12814

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