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SNU17P-PML1P structure intermediate during res complex assembly

Analyse SNU17P-PML1P structure intermediate during res complex assembly in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2MY3
Type
protein
Length
141 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
U2 snrnp component IST3; Pre-mRNA leakage protein 1
UniProt
P40565, Q07930
Pockets
1 · best druggability 0.29

Structure

solution nmr · 2 distinct chains · 28% helix, 20% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AU2 snrnp component IST3protein11831% helix, 24% strandP40565
BPre-mRNA leakage protein 1protein2313% helix, 0% strandQ07930

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1520.290.7514empty

Interfaces

1 interface between chains.

  • A–B · 902 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

  • 2MY3 · Snu17p-Pml1p structure intermediate during RES complex assembly · the same entry in another collection · chain B against B, TM-score 1.00
  • P40565 · AlphaFold monomer V2.0 prediction for U2 snrnp component IST3 (P40565) · a predicted model of the same protein · chain A against A, TM-score 0.76
  • Q07930 · AlphaFold monomer V2.0 prediction for pre-mRNA leakage protein 1 (Q07930) · a predicted model of the same protein · chain B against A, TM-score 0.25

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