Research workbench

NMR structure of the RAD18-UBZ/UBIQUITIN complex

Analyse NMR structure of the RAD18-UBZ/UBIQUITIN complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MRE
Type: protein
Length: 112 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyubiquitin-C; E3 ubiquitin-protein ligase RAD18
EC: 6.3.2.-
UniProt: P0CG48, Q9NS91
Ligands: ZN

Structure

solution nmr · 2 distinct chains · 22% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polyubiquitin-C	protein	79	18% helix, 33% strand	P0CG48
B	E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-)	protein	33	33% helix, 24% strand	Q9NS91

Ligands and binding sites

ZN · Zinc ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 555 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2MRE · NMR structure of the Rad18-UBZ/ubiquitin complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9NS91 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RAD18 (Q9NS91) · a predicted model of the same protein · chain B against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0CG48
Every structure of UniProt Q9NS91
Elsewhere: RCSB PDB 2MRE · PDBe 2MRE · UniProt P0CG48 · UniProt Q9NS91

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