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D-dopachrome tautomerase

Analyse D-dopachrome tautomerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1DPT
Type: protein
Length: 351 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: D-dopachrome tautomerase
UniProt: P30046
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	D-dopachrome tautomerase	protein	117	40% helix, 28% strand	P30046

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	291	0.56	0.76	25	empty
2	106	0.39	0.76	22	empty
3	65	0.36	0.77	14	empty

Interfaces

2 interfaces between chains.

A–B · 291 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 203 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1DPT · D-dopachrome tautomerase · the same entry in another collection · chain A against A, TM-score 1.00
P30046 · AlphaFold monomer V2.0 prediction for D-dopachrome decarboxylase (P30046) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30046
Elsewhere: RCSB PDB 1DPT · PDBe 1DPT · UniProt P30046

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