UniProt P30046
D-dopachrome decarboxylase (P30046)
D-dopachrome decarboxylase (UniProt P30046), EC 4.1.1.84: 17 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P30046
- Protein
- D-dopachrome decarboxylase
- EC
- 4.1.1.84
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 18 · 3 records with a druggable one
Structures
18 records of P30046 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DPT | D-dopachrome tautomerase | x-ray diffraction | A, B, C | — | — |
| 1DPT | D-dopachrome tautomerase | x-ray diffraction | A, B, C | — | — |
| 4Q3F | Human D-DT complexed with tartrate | x-ray diffraction | A, B, C | — | — |
| 4Q3F | Human D-dt complexed with tartrate | x-ray diffraction | A, B, C | — | — |
| 6C5F | Human D-dopachrome tautomerase (D-dt)/ macrophage migration inhibitory factor 2 (MIF2) complexed… | x-ray diffraction | A, B, C | 7L9 | — |
| 7MRU | Crystal structure of S62A MIF2 mutant | x-ray diffraction | A, B, C | — | — |
| 7MRV | F100A mutant structure of MIF2 (D-DT) | x-ray diffraction | A | SO4 | — |
| 7MRV | F100A mutant structure of MIF2 (D-dt) | x-ray diffraction | A | SO4 | — |
| 7MSE | High-resolution crystal structure of hMIF2 with tartrate at the active site | x-ray diffraction | A, B, C | — | — |
| 7MSE | High-resolution crystal structure of HMIF2 with tartrate at the active site | x-ray diffraction | A, B, C | — | — |
| 7MW7 | Crystal structure of P1G mutant of D-dopachrome tautomerase | x-ray diffraction | A | SO4 | — |
| 8DBB | Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid | x-ray diffraction | A, B, C | R3K | 5 (best 0.52) |
| 8VDY | Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | 8 (best 0.71) |
| 8VFO | Crystal Structure of L117G Variant of D-Dopachrome Tautomerase (D-DT) | x-ray diffraction | A | — | — |
| 8VG5 | Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC | x-ray diffraction | A, B, C, D | 7L9 | 3 (best 0.77) |
| 8VG7 | Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) | x-ray diffraction | A | — | 1 (best 0.33) |
| 8VG8 | Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Bound to 4CPPC | x-ray diffraction | A | 7L9 | 1 (best 0.42) |
| P30046 | AlphaFold monomer V2.0 prediction for D-dopachrome decarboxylase (P30046) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1DPT chain B against the predicted model P30046: TM-score 0.99, RMSD 0.37 Å
- 1DPT chain B against the predicted model P30046: TM-score 0.99, RMSD 0.37 Å
- 4Q3F chain B against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 4Q3F chain B against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 7MSE chain B against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 7MSE chain B against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 1DPT chain C against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 1DPT chain C against the predicted model P30046: TM-score 0.99, RMSD 0.39 Å
- 6C5F chain C against the predicted model P30046: TM-score 0.99, RMSD 0.40 Å
- 6C5F chain A against the predicted model P30046: TM-score 0.99, RMSD 0.40 Å
Elsewhere
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