Research workbench

Spatial structure of the toll-like receptor 3 transmembrane domain in the trimeric state

Analyse Spatial structure of the toll-like receptor 3 transmembrane domain in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MKA
Type: protein
Length: 102 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Toll-like receptor 3
UniProt: O15455
Pockets: 2 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 82% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Toll-like receptor 3	protein	34	82% helix, 0% strand	O15455

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	161	0.59	0.82	24	empty
2	73	0.39	0.78	18	empty

Interfaces

3 interfaces between chains.

A–B · 489 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 406 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 183 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2MKA · Spatial structure of the Toll-like receptor 3 transmembrane domain in the trimeric state · the same entry in another collection · chain A against A, TM-score 1.00
O15455 · AlphaFold monomer V2.0 prediction for toll-like receptor 3 (O15455) · a predicted model of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15455
Elsewhere: RCSB PDB 2MKA · PDBe 2MKA · UniProt O15455

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.