UniProt O15455
Toll-like receptor 3 (O15455)
Toll-like receptor 3 (UniProt O15455): 21 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15455
- Protein
- Toll-like receptor 3
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 62 · 5 records with a druggable one
Structures
22 records of O15455 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZIW | Human Toll-like Receptor 3 extracellular domain structure | x-ray diffraction | A | — | — |
| 1ZIW | Human toll-like receptor 3 extracellular domain structure | x-ray diffraction | A | — | — |
| 2A0Z | The molecular structure of toll-like receptor 3 ligand binding domain | x-ray diffraction | A | — | — |
| 2A0Z | The molecular structure of toll-like receptor 3 ligand binding domain | x-ray diffraction | A | — | — |
| 2MK9 | Spatial structure of the dimeric transmembrane domain of Toll-like receptor 3 | solution nmr | A, B | — | — |
| 2MK9 | Spatial structure of the dimeric transmembrane domain of toll-like receptor 3 | solution nmr | A, B | — | — |
| 2MKA | Spatial structure of the Toll-like receptor 3 transmembrane domain in the trimeric state | solution nmr | A, B, C | — | — |
| 2MKA | Spatial structure of the toll-like receptor 3 transmembrane domain in the trimeric state | solution nmr | A, B, C | — | — |
| 3ULU | Structure of quaternary complex of human TLR3ecd with three Fabs (Form1) | x-ray diffraction | A | — | — |
| 3ULU | Structure of quaternary complex of human TLR3ECD with three fabs (FORM1) | x-ray diffraction | A | — | — |
| 3ULV | Structure of quaternary complex of human TLR3ecd with three Fabs (Form2) | x-ray diffraction | A | — | — |
| 3ULV | Structure of quaternary complex of human TLR3ECD with three fabs (FORM2) | x-ray diffraction | A | — | — |
| 5GS0 | Crystal structure of the complex of TLR3 and bi-specific diabody | x-ray diffraction | A, B | — | — |
| 7C76 | Cryo-EM structure of human TLR3 in complex with UNC93B1 | electron microscopy | A | NAG | — |
| 7C76 | Cryo-EM structure of human TLR3 in complex with UNC93B1 | electron microscopy | A | NAG | — |
| 7WV3 | Toll-like receptor3 linear cluster | electron microscopy | A, B, C, D | NAG | 19 (best 0.66) |
| 7WV4 | ectoTLR3-poly(I:C) cluster | electron microscopy | A, B, C, D | — | 18 (best 0.75) |
| 7WV5 | ectoTLR3-poly(I:C) | electron microscopy | A, B | NAG | 6 (best 0.73) |
| 7WVE | CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex | electron microscopy | A, B | — | 8 (best 0.75) |
| 7WVJ | NT-mut(K117D,K139D,K145D) TLR3 -poly I:C complex | electron microscopy | A, B | — | 9 (best 0.61) |
| 8AR1 | Solution structure of TLR3 transmembrane and cytoplasmic juxtamembrane regions | solution nmr | A | — | 1 (best 0.33) |
| O15455 | AlphaFold monomer V2.0 prediction for toll-like receptor 3 (O15455) | predicted | A | — | 1 (best 0.39) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
Experiment against prediction
- 1ZIW chain A against the predicted model O15455: TM-score 1.00, RMSD 0.54 Å
- 1ZIW chain A against the predicted model O15455: TM-score 1.00, RMSD 0.54 Å
- 2A0Z chain A against the predicted model O15455: TM-score 0.99, RMSD 0.90 Å
- 2A0Z chain A against the predicted model O15455: TM-score 0.99, RMSD 0.90 Å
- 5GS0 chain A against the predicted model O15455: TM-score 0.99, RMSD 0.95 Å
- 7WV5 chain A against the predicted model O15455: TM-score 0.99, RMSD 1.05 Å
- 7WV4 chain A against the predicted model O15455: TM-score 0.98, RMSD 1.12 Å
- 7WVE chain A against the predicted model O15455: TM-score 0.98, RMSD 1.15 Å
- 7WV3 chain A against the predicted model O15455: TM-score 0.98, RMSD 1.17 Å
- 7WVJ chain A against the predicted model O15455: TM-score 0.98, RMSD 1.16 Å
Elsewhere
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