Research workbench
Crystal structure of a chimera of beta-catenin and alpha- catenin
Analyse Crystal structure of a chimera of beta-catenin and alpha- catenin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DOW
- Type
- protein
- Length
- 237 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-catenin; Beta-catenin
- UniProt
- P26231, Q02248
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-catenin | protein | 205 | 88% helix, 0% strand | P26231 |
| B | Beta-catenin | protein | 32 | 66% helix, 0% strand | Q02248 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.53 | 0.80 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1342 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1DOW · Crystal structure of a chimera of beta-catenin and alpha-catenin · the same entry in another collection · chain A against A, TM-score 1.00
- P26231 · AlphaFold monomer V2.0 prediction for catenin alpha-1 (P26231) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q02248 · AlphaFold monomer V2.0 prediction for catenin beta-1 (Q02248) · a predicted model of the same protein · chain B against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26231
- Every structure of UniProt Q02248
- Elsewhere: RCSB PDB 1DOW · PDBe 1DOW · UniProt P26231 · UniProt Q02248
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