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Solution structure of the third double-stranded RNA-binding domain (DSRBD3) of human adenosine-deaminase ADAR1

Analyse Solution structure of the third double-stranded RNA-binding domain (DSRBD3) of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2MDR
Type: protein
Length: 94 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Double-stranded RNA-specific adenosine deaminase
EC: 3.5.4.37
UniProt: P55265
Pockets: 2 · best druggability 0.35

Structure

solution nmr · 1 distinct chain · 44% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Double-stranded RNA-specific adenosine deaminase (EC 3.5.4.37)	protein	94	44% helix, 24% strand	P55265

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.35	0.79	13	empty
2	63	0.29	0.74	12	empty

Compared structures

2MDR · Solution structure of the third double-stranded RNA-binding domain (dsRBD3) of human… · the same entry in another collection · chain A against A, TM-score 1.00
P55265 · AlphaFold monomer V2.0 prediction for double-stranded RNA-specific adenosine deaminase… · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55265
Elsewhere: RCSB PDB 2MDR · PDBe 2MDR · UniProt P55265

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